几组关于癌症的信息

Top mutations in cancer: (36 keys)

ABL1
AKT1
ALK
APC
BRAF
CDKN2A
CSF1R
CTNNB1
EGFR
ERBB2
EZH2
FBXW7
FGFR3
FLT3
GNAQ
GNAS
HRAS
IDH1
IDH2
JAK2
KIT
KRAS
MET
NF2
NOTCH1
NPM1
NRAS
PDGFRA
PIK3CA
PTEN
RB1
RET
SRC
STK11
TP53
VHL

Top 9 pathways dysfunctional in cancer:

Angiogenesis: ANGPT1, ANGPT2, CCL2 (MCP-1), FGF2 (bFGF), FLT1, KDR, PGF, SERPINF1, TEK (TIE2), VEGFC.

Apoptosis: APAF1, BCL2L11, BIRC3 (c-IAP1), CASP2, CASP7, CASP9, CFLAR (CASPER), FASLG (TNFSF6), NOL3, XIAP.

Cell Cycle: AURKA, CCND2, CCND3, CDC20, E2F4, MCM2, MKI67, SKP2, STMN1, WEE1.

Cell Senescence: BMI1 (PCGF4), ETS2, IGFBP3, IGFBP5, IGFBP7, MAP2K1, MAP2K3, MAPK14, SERPINB2 (PAI-2), SOD1, TBX2.

DNA Damage & Repair: DDB2, DDIT3 (GADD153/CHOP), ERCC3 (XPB), ERCC5, GADD45G, LIG4, POLB, PPP1R15A (GADD34).

Epithelial-to-Mesenchymal Transition: CDH2 (N-cadherin), DSP, FOXC2, GSC, KRT14, OCLN, SNAI1, SNAI2, SNAI3, SOX10.

Hypoxia: ADM, ARNT, CA9, EPO, HMOX1, LDHA, SLC2A1.

Metabolism: ACLY, ACSL4, ATP5A1, COX5A, CPT2, G6PD, GPD2, LPL, PFKL, UQCRFS1.

Telomeres & Telomerase: DKC1, PINX1, TEP1, TERF1, TERF2IP, TINF2, TNKS (TIN1), TNKS2.

miRNA regulation in cancer:

cel-miR-39-3p, hsa-let-7a-5p, hsa-let-7a-3p, hsa-let-7b-5p, hsa-let-7b-3p, hsa-let-7c-5p, hsa-let-7d-5p, hsa-let-7e-5p, hsa-let-7e-3p, hsa-let-7f-5p, hsa-let-7g-5p, hsa-let-7i-5p, hsa-let-7i-3p, hsa-miR-1, hsa-miR-100-5p, hsa-miR-100-3p, hsa-miR-101-3p, hsa-miR-103a-3p, hsa-miR-105-5p, hsa-miR-106a-3p, hsa-miR-106b-5p, hsa-miR-106b-3p, hsa-miR-107, hsa-miR-10a-5p, hsa-miR-10a-3p, hsa-miR-10b-5p, hsa-miR-1204, hsa-miR-1207-3p, hsa-miR-122-5p, hsa-miR-1228-5p, hsa-miR-1228-3p, hsa-miR-124-3p, hsa-miR-125a-5p, hsa-miR-125a-3p, hsa-miR-125b-5p, hsa-miR-125b-1-3p, hsa-miR-126-5p, hsa-miR-126-3p, hsa-miR-127-3p, hsa-miR-127-5p, hsa-miR-1275, hsa-miR-128-3p, hsa-miR-1285-3p, hsa-miR-1287-5p, hsa-miR-129-5p, hsa-miR-130a-3p, hsa-miR-130a-5p, hsa-miR-130b-3p, hsa-miR-132-3p, hsa-miR-132-5p, hsa-miR-133a-3p, hsa-miR-133b, hsa-miR-134-5p, hsa-miR-135a-5p, hsa-miR-135a-3p, hsa-miR-135b-5p, hsa-miR-135b-3p, hsa-miR-136-5p, hsa-miR-137, hsa-miR-138-5p, hsa-miR-139-5p, hsa-miR-139-3p, hsa-miR-140-5p, hsa-miR-140-3p, hsa-miR-141-3p, hsa-miR-141-5p, hsa-miR-142-5p, hsa-miR-142-3p, hsa-miR-143-3p, hsa-miR-144-3p, hsa-miR-144-5p, hsa-miR-145-5p, hsa-miR-145-3p, hsa-miR-146a-5p, hsa-miR-146a-3p, hsa-miR-146b-5p, hsa-miR-146b-3p, hsa-miR-147a, hsa-miR-148a-3p, hsa-miR-148a-5p, hsa-miR-148b-3p, hsa-miR-148b-5p, hsa-miR-149-5p, hsa-miR-149-3p, hsa-miR-150-5p, hsa-miR-151a-3p, hsa-miR-152-3p, hsa-miR-153-3p, hsa-miR-154-5p, hsa-miR-154-3p, hsa-miR-155-5p, hsa-miR-155-3p, hsa-miR-15a-5p, hsa-miR-15b-5p, hsa-miR-15b-3p, hsa-miR-16-5p, hsa-miR-17-5p, hsa-miR-17-3p, hsa-miR-181a-5p, hsa-miR-181a-3p, hsa-miR-181b-5p, hsa-miR-181b-3p, hsa-miR-181c-5p, hsa-miR-181d-5p, hsa-miR-182-5p, hsa-miR-182-3p, hsa-miR-183-5p, hsa-miR-183-3p, hsa-miR-184, hsa-miR-185-5p, hsa-miR-185-3p, hsa-miR-186-5p, hsa-miR-187-3p, hsa-miR-18a-5p, hsa-miR-18a-3p, hsa-miR-18b-5p, hsa-miR-190a-5p, hsa-miR-191-5p, hsa-miR-191-3p, hsa-miR-192-5p, hsa-miR-192-3p, hsa-miR-193a-3p, hsa-miR-193a-5p, hsa-miR-193b-3p, hsa-miR-193b-5p, hsa-miR-194-5p, hsa-miR-194-3p, hsa-miR-195-5p, hsa-miR-195-3p, hsa-miR-196a-5p, hsa-miR-196a-3p, hsa-miR-196b-5p, hsa-miR-197-3p, hsa-miR-198, hsa-miR-199a-5p, hsa-miR-199a-3p, hsa-miR-199b-5p, hsa-miR-19a-3p, hsa-miR-19a-5p, hsa-miR-19b-3p, hsa-miR-200a-3p, hsa-miR-200a-5p, hsa-miR-200b-3p, hsa-miR-200b-5p, hsa-miR-200c-3p, hsa-miR-200c-5p, hsa-miR-202-3p, hsa-miR-203a, hsa-miR-204-5p, hsa-miR-204-3p, hsa-miR-205-5p, hsa-miR-205-3p, hsa-miR-206, hsa-miR-20a-5p, hsa-miR-20a-3p, hsa-miR-20b-5p, hsa-miR-20b-3p, hsa-miR-21-5p, hsa-miR-21-3p, hsa-miR-210-3p, hsa-miR-211-5p, hsa-miR-211-3p, hsa-miR-212-3p, hsa-miR-214-3p, hsa-miR-215-5p, hsa-miR-216a-5p, hsa-miR-216b-5p, hsa-miR-217, hsa-miR-218-5p, hsa-miR-219a-5p, hsa-miR-22-3p, hsa-miR-22-5p, hsa-miR-221-3p, hsa-miR-222-3p, hsa-miR-222-5p, hsa-miR-223-3p, hsa-miR-223-5p, hsa-miR-224-5p, hsa-miR-224-3p, hsa-miR-23a-3p, hsa-miR-23a-5p, hsa-miR-23b-3p, hsa-miR-23b-5p, hsa-miR-24-3p, hsa-miR-25-3p, hsa-miR-25-5p, hsa-miR-26a-5p, hsa-miR-26b-5p, hsa-miR-26b-3p, hsa-miR-27a-3p, hsa-miR-27a-5p, hsa-miR-27b-3p, hsa-miR-27b-5p, hsa-miR-28-5p, hsa-miR-296-5p, hsa-miR-297, hsa-miR-298, hsa-miR-29a-3p, hsa-miR-29a-5p, hsa-miR-29b-3p, hsa-miR-29c-3p, hsa-miR-29c-5p, hsa-miR-301a-3p, hsa-miR-302a-3p, hsa-miR-302b-5p, hsa-miR-302b-3p, hsa-miR-302c-3p, hsa-miR-302d-3p, hsa-miR-30a-5p, hsa-miR-30a-3p, hsa-miR-30b-5p, hsa-miR-30b-3p, hsa-miR-30c-5p, hsa-miR-30d-5p, hsa-miR-30d-3p, hsa-miR-30e-5p, hsa-miR-30e-3p, hsa-miR-31-5p, hsa-miR-32-5p, hsa-miR-32-3p, hsa-miR-320a, hsa-miR-323a-3p, hsa-miR-323a-5p, hsa-miR-324-5p, hsa-miR-325, hsa-miR-326, hsa-miR-328-3p, hsa-miR-330-3p, hsa-miR-331-3p, hsa-miR-331-5p, hsa-miR-335-5p, hsa-miR-335-3p, hsa-miR-337-3p, hsa-miR-338-3p, hsa-miR-339-5p, hsa-miR-33a-5p, hsa-miR-33a-3p, hsa-miR-33b-5p, hsa-miR-340-3p, hsa-miR-340-5p, hsa-miR-342-3p, hsa-miR-345-5p, hsa-miR-345-3p, hsa-miR-346, hsa-miR-34a-5p, hsa-miR-34a-3p, hsa-miR-34b-3p, hsa-miR-34c-5p, hsa-miR-34c-3p, hsa-miR-361-5p, hsa-miR-363-3p, hsa-miR-365a-3p, hsa-miR-367-3p, hsa-miR-370-3p, hsa-miR-371a-3p, hsa-miR-372-3p, hsa-miR-373-3p, hsa-miR-374a-5p, hsa-miR-374a-3p, hsa-miR-375, hsa-miR-376a-3p, hsa-miR-376b-3p, hsa-miR-376c-3p, hsa-miR-377-3p, hsa-miR-378a-3p, hsa-miR-379-5p, hsa-miR-379-3p, hsa-miR-381-3p, hsa-miR-382-5p, hsa-miR-383-5p, hsa-miR-409-5p, hsa-miR-409-3p, hsa-miR-410-3p, hsa-miR-421, hsa-miR-422a, hsa-miR-423-3p, hsa-miR-423-5p, hsa-miR-424-5p, hsa-miR-425-5p, hsa-miR-429, hsa-miR-432-5p, hsa-miR-433-3p, hsa-miR-449a, hsa-miR-449b-5p, hsa-miR-451a, hsa-miR-452-5p, hsa-miR-455-5p, hsa-miR-455-3p, hsa-miR-483-3p, hsa-miR-483-5p, hsa-miR-484, hsa-miR-485-5p, hsa-miR-486-5p, hsa-miR-486-3p, hsa-miR-487b-3p, hsa-miR-488-3p, hsa-miR-489-3p, hsa-miR-491-5p, hsa-miR-492, hsa-miR-493-5p, hsa-miR-493-3p, hsa-miR-494-3p, hsa-miR-495-3p, hsa-miR-497-5p, hsa-miR-497-3p, hsa-miR-498, hsa-miR-499a-5p, hsa-miR-500a-5p, hsa-miR-503-5p, hsa-miR-504-5p, hsa-miR-506-3p, hsa-miR-506-5p, hsa-miR-507, hsa-miR-508-3p, hsa-miR-511-5p, hsa-miR-512-3p, hsa-miR-514a-3p, hsa-miR-517a-3p, hsa-miR-518b, hsa-miR-518c-3p, hsa-miR-519a-3p, hsa-miR-519c-3p, hsa-miR-519d-3p, hsa-miR-519e-3p, hsa-miR-520b, hsa-miR-520c-3p, hsa-miR-520e, hsa-miR-520g-3p, hsa-miR-524-3p, hsa-miR-542-5p, hsa-miR-542-3p, hsa-miR-552-3p, hsa-miR-570-3p, hsa-miR-584-5p, hsa-miR-586, hsa-miR-588, hsa-miR-592, hsa-miR-596, hsa-miR-601, hsa-miR-605-5p, hsa-miR-607, hsa-miR-608, hsa-miR-616-3p, hsa-miR-622, hsa-miR-625-5p, hsa-miR-629-5p, hsa-miR-630, hsa-miR-635, hsa-miR-637, hsa-miR-650, hsa-miR-652-3p, hsa-miR-652-5p, hsa-miR-661, hsa-miR-663a, hsa-miR-7-5p, hsa-miR-708-5p, hsa-miR-744-5p, hsa-miR-765, hsa-miR-885-5p, hsa-miR-885-3p, hsa-miR-9-5p, hsa-miR-9-3p, hsa-miR-92a-3p, hsa-miR-92b-3p, hsa-miR-93-5p, hsa-miR-95-3p, hsa-miR-96-5p, hsa-miR-96-3p, hsa-miR-98-5p, hsa-miR-99a-5p, hsa-miR-99a-3p, hsa-miR-99b-5p, hsa-miR-99b-3p

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